DEFINE THE SYSTEMIC INFLAMMATORY RESPONSE SYNDROME, SEPSIS, SEVERE SEPSIS, SEPTIC SHOCK, AND MULTIPLE ORGAN DYSFUNCTION SYNDROME.

DEFINE THE SYSTEMIC INFLAMMATORY RESPONSE SYNDROME, SEPSIS, SEVERE SEPSIS, SEPTIC SHOCK, AND MULTIPLE ORGAN DYSFUNCTION SYNDROME.

a) Define the systemic inflammatory response syndrome, sepsis, severe sepsis,
septic shock, and multiple organ dysfunction syndrome using current veterinary
terminology and clinical criteria in dogs. (15 marks)
b) Briefly compare and contrast the pathophysiology of the initial immune response
to non-infectious versus infectious insults, giving examples of specific insults
and molecular patterns sensed by the host. (5 marks)
c) Describe the innate immune response to gram negative bacterial infection
including key mediators of the subsequent clinical syndrome. (20 marks)
d) Draw a diagram showing determinants of oxygen delivery (DO2), then work
through the algorithm discussing in detail the parameters affected by sepsis, and
how each may be affected. (10 marks)
e) Outline your treatment approach to septic shock in dogs; be specific with drugs
and doses, and compare your approach to current guidelines in human medicine.
Do not include the general management strategies for sepsis (i.e. antibiotics or
source control) in your answer. Include second line therapies, monitoring and/or
end-points. (10 marks)

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