The starting point of the assignment is “The D614G mutation in the SARS-CoV-2 spike protein reduces S1shedding and increases infectivity” article, in addition to other articles under COVID special topics. The assignment presents truly open ended question and there is no single correct answer here. You will be graded based on the depth of your presented thinking and appropriateness of methodologies for the posed questions.
Please be as thorough as possible in your descriptions, but do NOT copy and paste directly from any sources. Page limit is two pages 1.5 spacing, times new roman font 11, margins 1 inch on all sides. Upload you assignment as pdf. Any references you wish to attach do not count toward the page limit
At the end of the conclusions section, the authors state:
“In summary, we show that an S protein mutation that results in more transmissible SARS-CoV-2 also limits shedding of the S1 domain and increases S-protein incorporation into the virion. Further studies will be necessary to determine the impact ofthis change on the nature and severity of COVID-19.”
Your goal is to suggest a basic outline of a possible follow up study that further addresses the enhanced stability of the mutant protein. You need to address the following: which protein variants (specifics domains, cleavages, mutations, derivatives etc) you wish to work with; your suggested means of sample preparation; your suggested biophysical characterization methodologies ( on which variants) to study the stability; your suggested additional experimental and/or modeling studies to address underlying structural variations. You are welcome to attach images from the pymol program, but this is NOT a required component for this assignment.
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