Mrs. P, a 31-year-old woman, had an uneventful first pregnancy. At 16 weeks’ gestation, a triple screen blood test was normal, indicating a 1/275 risk of Down Syndrome; based on this test result, prenatal diagnosis was not considered. An ultrasound examination performed at 18 weeks’ gestation revealed no abnormalities. Mrs. P’s family history is significant for a 12-year old maternal first cousin with Down syndrome.  Her physician raises the possibility of prenatal diagnosis for chromosomal disorders because of Mrs. P family history. Mrs. P and her husband were both hesitant proceeding with the genetic testing. Thank


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